Wip1 downregulation conserves truncated DNA damage response (DDR) in mitosis
نویسندگان
چکیده
Comment on: Macurek L, et al. Cell Cycle 2012; 12:251-62.
منابع مشابه
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint
The DNA damage response (DDR) pathway and its core component tumor suppressor p53 block cell cycle progression after genotoxic stress and represent an intrinsic barrier preventing cancer development. The serine/threonine phosphatase PPM1D/Wip1 inactivates p53 and promotes termination of the DDR pathway. Wip1 has been suggested to act as an oncogene in a subset of tumors that retain wild-type p5...
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